姓名：张强
职称：讲师
专业：化学
所属二级学科：分析化学
研究方向：功能核酸生物传感、肿瘤免疫分析
E-mail: [email protected]
个人简历：张强，男，一本道 讲师。2024年毕业于湖南大学分析化学专业，师从谭蔚泓教授。主要从事于分析化学与分子医学交叉领域的研究，重点包括功能核酸分子设计与肿瘤免疫疗法。目前，在ACS Central Science、Nano Letters等期刊发表17篇SCI论文。曾获一本道 第四届创新创业“校长奖章”，一本道 第一届“科技之星”，最具影响力毕业生等荣誉称号及东宝集团命名奖学金等。
近年来的主要研究工作：
1. 功能核酸分子探针的设计与应用：采用膜锚定的三维DNA探针，在细胞膜界面构建了一系列DNA反应回路，模拟肿瘤免疫中的受体-配体相互作用，响应细胞释放的信号分子，驱动新的细胞-细胞互作网络。
2.基于核酸适体的T细胞免疫疗法开发：针对CAR-T疗法在实体瘤临床应用中的活性调控难题和脱靶问题，设计了核酸适体功能化CAR结构，通过调节核酸适体与抗原结合的亲和力和特异性，实现对CAR-T细胞活性和特异性的精准调控，且无需复杂的基因工程设计。
近年来承担的主要项目（五项）：
1.中央高校基本科研业务费
2.化学生物传感全国重点实验室开放课题资助项目
近年来发表的代表性论文（十篇）：
1. Zhiwei Yin#, Ling Li#, Qiang Zhang#, Xiaoshen Zhang#, Rui Shi, Xin Xia, Zhaoxin Wang, Shengkai Li, Mao Ye, Yanlan Liu, Weihong Tan, and Zhuo Chen*. PerC B-Cells Activation via Thermogenetics-Based CXCL12 Generator for Intraperitoneal Immunity Against Metastatic Disseminated Tumor Cells, Advanced Materials, 2025, 2411731.
2. Qiang Zhang#, Yue Zhang#, Limei Wu, Dan Wang, Yuting Zhuo, Yao Lu, Yue Liu, Zhimin Wang, Liping Qiu*, and Weihong Tan*. DNA Reaction Circuits to Establish Designated Biological Functions in Multicellular Community. Nano Letters, 2024, 24(19), 5808–5815.
3. Qiang Zhang, Limei Wu, Yue Zhang, Dan Wang, Yingyu Sima, Zhimin Wang, Zhimin Wang, Zhiwei Yin, Hui Wu, Yuting Zhuo, Yutong Zhang, Linlin Wang, Yong Chen, Yanlan Liu, Liping Qiu*, and Weihong Tan*. Aptamer-Based Nongenetic Reprogramming of CARs Enables Flexible Modulation of T Cell-Mediated Tumor Immunotherapy. ACS Central Science, 2024, 10(4):813-822.
4. Zhiyong Huang#, Dan Wang#, Qiang Zhang#, Yutong Zhang, Ruizi Peng*, and Weihong Tan*. Leveraging Aptamer-Based DNA Nanotechnology for Bioanalysis and Cancer Therapeutics. Accounts of Materials Research, 2024, 5(4): 438–452.
5. Yong-Hao Ma, Yan Zhu, Hui Wu, Yao He, Qiang Zhang, Qiuling Huang, Zhimin Wang, Hang Xing, Liping Qiu*, and Weihong Tan. Domain-Targeted Membrane Partitioning of Specific Proteins with DNA Nanodevices. Journal of the American Chemical Society, 2024, 146(11): 7640–7648.
6. Yulin Du, Yifan Lyu, Jie Lin, Chunran Ma, Qiang Zhang, Yutong Zhang, Liping Qiu*, Weihong Tan*. Membrane-Anchored DNA Nanojunctions Enable Closer Antigen-Presenting Cell–T-Cell Contact in Elevated T-Cell Receptor Triggering. Nature Nanotechnology, 2023,18(7): 818-827.
7. Zhimin Wang, Yue Zhang, Limei Wu, Jianghuai Chen, Sitao Xie, Jiaxuan He, Qiang Zhang, Hong Chen, Fengming Chen, Yue Liu, Yutong Zhang, Yuting Zhuo, Nachuan Wen, Liping Qiu*, and Weihong Tan. An Aptamer-Functionalized DNA Circuit to Establish an Artificial Interaction between T Cells and Cancer Cells. Angewandte Chemie International Edition, 2023, 62(39): e202307656.
8. Qiang Zhang, Yan Xu*, Zhuopeng Wang, Xia Zhang, Zhiguo Xia. BiOBr-Assisted Hydrothermal Synthesis of Hierarchical Bi4(GeO4)3/Zn2GeO4 Microspheres for Optical Sensor Application, Journal of Materials Chemistry C, 2018, 36(6): 9778-9785.
