姓名：徐章润
职称：教授
专业：化学
所属二级学科：分析化学
研究方向：微流控分析、光谱分析、生物分析
E-mail: [email protected]
电话：024-86387659
个人简历：毕业于一本道 化学系，师从方肇伦院士获博士学位，曾在美国加州大学伯克利分校做访问学者。先后入选教育部新世纪优秀人才支持计划、辽宁省百千万人才工程百人层次、沈阳市高层次人才领军人才。先后主持国家自然科学基金仪器专项项目和国家自然科学基金面上项目7项。在国内外重要学术期刊发表论文120余篇，授权国家发明专利6项，作为主要完成人获辽宁省自然科学一等奖和教育部自然科学一等奖。
近年来的主要研究工作：
1. 围绕疾病标志物检测研究方向，以微流控芯片为平台，先进光谱分析技术为手段，开展生命样品、特别是肿瘤标志物的检测新方法研究。
2. 发展端粒酶活性可视化检测、高灵敏度小细胞外囊泡检测等生命物质分析方法，主要解决生命样品分析中灵敏度低、准确性差等科学问题。
近年来承担的主要项目：
1.国家自然科学基金项目：基于血行转移芯片的Wnt通路关键调控分子实时成像及其调控肿瘤转移的协同作用研究，项目起止年月：2024年01月至2027年12月。
2.国家自然科学基金项目：单细胞水平的端粒酶活性可视化检测新方法的研究，项目起止年月：2019年01月至2022年12月。
近年来发表的代表性论文：
1.Tingju Ren, Yingzhi Zhang, Yuxiao Tong, Qi Zhang, Tianhao Wang, Yue Wang, Chunguang Yang, Zhangrun Xu*. FRET imaging of glycoRNA on small extracellular vesicles enabling sensitive cancer diagnostics. Nature Communications, 2025, 16: 3391.
2.Tingju Ren, Yingzhi Zhang, Qi Zhang, Meilun Tan, Jiahui Gu, Yuxiao Tong, Yue Wang, Chunguang Yang, Zhangrun Xu*. Accurate cancer diagnosis and treatment monitoring through multiplexed profiling of protein markers on small extracellular vesicles. ACS Nano, 2025, //doi.org/10.1021/acsnano.5c02864
3.Qi Zhang, Ruofei Ma, Siwen Chen, Ke Cao, Yue Wang, Zhangrun Xu*. Biomineralized and metallized small extracellular vesicles encapsulated in hydrogels for mitochondrial-targeted synergistic tumor therapy. Acta Biomaterialia, 2025, 194: 428-441.
4.Qi Zhang, Ruofei Ma, Yingzhi Zhang, Jing Zhao, Yue Wang, Zhangrun Xu*. Dual-aptamer-assisted ratiometric SERS biosensor for ultrasensitive and precise identification of breast cancer exosomes. ACS Sensors, 2023, 8: 875-883.
5.Wenqi Ye, Xiaopeng Liu, Ruofei Ma, Chunguang Yang, Zhangrun Xu*. Open-channel microfluidic chip based on shape memory polymer for controllable liquid transport. Lab on a Chip, 2023, 23: 2068-2074.
6.Jie Wang, Xiaopeng Liu, Wanyi Xue, Yunyun Wei, Zhangrun Xu*. Highly sensitive monitoring of telomerase activity in living cells based on rapidly triggered cascade amplification reaction. Biosensors and Bioelectronics, 2022, 216: 114645.
7.Yingzhi Zhang, Yunyun Wei, Peng Liu, Xuan Zhang, Zhangrun Xu*, Xiaodong Tan, Mingli Chen, Jianhua Wang. ICP-MS and photothermal dual-readout assay for ultrasensitive and point-of-care detection of pancreatic cancer exosomes. Analytical Chemistry, 2021, 93: 11540-11546
8.Yingzhi Zhang, Junye Jiao, Yunyun Wei, Danni Wang, Chunguang Yang*, Zhangrun Xu*. A plasmonic colorimetric biosensor for sensitive exosome detection via enzyme-induced etching of gold nanobipyramid@MnO2 nanosheet nanostructures. Analytical Chemistry, 2020, 92: 15244-15252.
9.Yue Wang, Jing Liu, Yukihiro Ozaki*, Zhangrun Xu*, Bing Zhao*. Effect of TiO2 on altering direction of interfacial charge transfer in a TiO2-Ag-MPY-FePc system by SERS. Angewandte Chemie International Edition, 2019, 131: 8256-8260.
Danni Wang, Rui Guo, Yunyun Wei, Yingzhi Zhang, Xiayu Zhao, Zhangrun Xu*. Sensitive multicolor visual detection of telomerase activity based on catalytic hairpin assembly and etching of Au nanorods. Biosensors and Bioelectronics, 2018, 122: 247-253.
