姓名：陈帅
职称：副教授
专业：化学
所属二级学科：物理化学
研究方向：智能传感/智能成像
E-mail: [email protected]
个人简历：
近年来的主要研究工作：
1.利用DNA荧光探针传感成像技术进行细胞/细胞器等传感分型分析，多维识别和信号单元调控。
2.创新荧光编码技术，开发多重编码探针，结合人工智能算法，用于多目标物数字检测。
3.应用人工智能技术，开发图像多模式识别算法，用于药物作用机制的快速识别筛选。
近年来承担的主要项目（五项）：
1.国家自然科学基金-面上项目，智能高维荧光成像用于揭示细胞功能异质性的分子形态学分析，2025-01-01至2028- 12-31
2.国家自然科学基金-青年科学基金项目，功能化石墨烯量子点在肿瘤多模态成像与识别中的应用研究，2017.01-2019.12
3.广东省自然科学基金，深度学习辅助多维荧光成像用于细胞器亚型分析，2024-01-01 至 2026-12-31
4.中央高校基本科研业务费项目，基于细胞荧光成像的药物机理快速分析, 2022-01 至 2023-12
5.辽宁省自然科学基金面上项目，单细胞荧光成像分析的生物医学应用研究，2021-08 至 2023-07
近年来发表的代表性论文（十篇）：
1.Yun Wen, Li-Ping Wang, Jian-Hua Wang, Yong-Liang Yu, Shuai Chen*. Computer-Aided Design of 3D Non-Enzymatic Catalytic Cascade Systems for In Situ Multiplexed mRNA Imaging in Single-Cells. Anal. Chem. 2025, 97, 7, 4176–4184.
2.Yu Zhang, Meng-Xian Liu, Yong-Liang Yu, Shuai Chen*. Frost-resistant hydrogel colorimetric sensing array for accurate detection of foodborne pathogens in cold chain systems. Biosens. Bioelectron. 2025, 271, 116990.
3.Guang-Yue Zou, Fan Bi, Yong-Liang Yu, Meng-Xian Liu*, Shuai Chen*, Tetrahedral DNA-Based Ternary Recognition Ratiometric Fluorescent Probes for Real-Time In Situ Resolving Lysosome Subpopulations in Living Cells via Cl–, Ca2+, and pH. Anal. Chem. 2024, 96, 42, 16639-16648.
4.Yun Wen, Wen-Ye Liu, Jian-Hua Wang, Yong-Liang Yu, and Shuai Chen*. Simultaneous Imaging of Multiple miRNAs in Mitochondria Controlled by Fluorescently Encoded Upconversion Optical Switches for Drug Resistance Studies. Analytical Chemistry, 2023, 95, 12152–12160.
5.Xue-Wei Zhang#, Gong-Xiang Qi#, Meng-Xian Liu, Yan-Fei Yang, Jian-Hua Wang, Yong-Liang Yu, and Shuai Chen*. Deep Learning Promotes Profiling of Multiple miRNAs in Single Extracellular Vesicles for Cancer Diagnosis. ACS sensors. 2024, 9, 3, 1555–1564.
6.Zhang, Xue-Wei; Qi, Gong-Xiang; Chen, Shuai*; Yu, Yong-Liang*; Wang, Jian-Hua. Ultrasensitive and Wash-Free Detection of Tumor Extracellular Vesicles by Aptamer-Proximity-Ligation-Activated Rolling Circle Amplification Coupled to Single Particle ICP-MS. Analytical Chemistry, 2024, 96(26): 10800-10808.
7.Xue-Wei Zhang, Yan-Fei Yang, Gong-Xiang Qi, Fu-Heng Zhai, Teng Fei, Yong-Liang Yu, Shuai Chen* and Jian-Hua Wang. Rapid and Accurate Identification of Drug Mechanism with Single-Cell Fluorescence Images via Deep Learning. Analytical Chemistry, 2023, 95, 8113–8120.
8.Meng-Xian Liu, Xiao-Bing Chen, Wen-Ye Liu, Guang-Yue Zou, Yong-Liang Yu*, Shuai Chen*, and Jian-Hua Wang. Dual Functional Full-color Carbon Dots-based Organelle Biosensor Array for Visualization of Lipid Droplet Subgroups with Varying Lipid Composition in Living Cells. Analytical Chemistry, 2023, 95, 5087–5094.
9.Yun Wen, Xue-Wei Zhang, Yuan-Yuan Li, Shuai Chen*, Yong-Liang Yu*, and Jian-Hua Wang. Ultramultiplex NaLnF4 Nanosatellites Combined with ICP-MS for Exosomal Multi-miRNA Analysis and Cancer Classification. Anal. Chem. 2022, 94, 46, 16196–16203.
10.Fuheng Zhai, Qing-Qing Zhan, Binbing Zhu, Shuai Chen* and Ronghuan He*. A deep learning protocol for analyzing and predicting ionic conductivity of anion exchange membranes. Journal of Membrane Science, 2022, 642:119983.
